Indications for Use InterCollagen® Guide can be used in guided bone regeneration (GBR) and guided tissue regeneration (GTR) procedures as a biodegradable barrier for: Periodontal bone defects (1-3 wall defects) and furcation defects (class I and II) After apicectomy, cystectomy, resection of retained teeth, and resection of other bone lesions Sinus floor augmentation and support of the Schneiderian membrane Maxillary ridge augmentation Maxillary ridge reconstruction for prosthetic treatment Extraction sockets after tooth extractions Immediate or delayed augmentation around implants in extraction sockets Surgical bone defects and bone wall defects Dehiscence and fenestration defects Studies InterCollagen® is a resorbable cross-linked membrane that promotes rapid healing. It exhibits excellent drapability, long-term stability and is easily suturable. InterCollagen® Guide is validated and documented in case of studies through clinicians involving procedures such as horizontal/vertical augmentation, sinus augmentation, and sinus elevation.

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Description SigmaOss™ is an allograft that can be used alone or in combination with other grafting materials. It is available in a range of types, and each type behaves and generates results differently depending on the clinical needs which are primarily volume preservation and/or rapid regeneration. SigmaOss™ is ideal for cases such as ridge augmentation, periodontal defect, sinus grafting, extraction site preservation, and more. Cortical Type Mineralized or Demineralized SMALL LARGE Volume MCOSG025 MCOLG025 0.25 cc MCOSG050 MCOLG050 0.5 cc MCOSG100 MCOLG100 1.0 cc MCOSG200 MCOLG200 2.0 cc SMALL Volume DCOSG025 0.25 cc DCOSG050 0.5 cc DCOSG100 1.0 cc DCOSG200 2.0 cc Cancellous Type Mineralized SMALL LARGE Volume MCASG025 MCALG025 0.25 cc MCASG050 MCALG050 0.5 cc MCASG100 MCALG100 1.0 cc MCASG200 MCALG200 2.0 cc Corticocancellous Type Mineralized or Demineralized SMALL LARGE Volume MCCSG025 MCCLG025 0.25 cc MCCSG050 MCCLG050 0.5 cc MCCSG100 MCCLG100 1.0 cc MCCSG200 MCCLG200 2.0 cc SMALL Volume DCCSG025 0.25 cc DCCSG050 0.5 cc DCCSG100 1.0 cc DCCSG200 2.0 cc Indications for Use ApplicationRidge augmentation, periodontal defect, sinus grafting, extraction site preservation SafetyMade possible through the generosity of American donors whose eligibility (screening and testing) is performed in accordance with AATB standards and FDA regulations VersatilityCapable of grafted alone or in combination with other grafting materials Capabilities Cortical TypeSlow-resorbing characteristic allows for extended period of space maintenance Cancellous TypeIdeal for defects that require rapid remodeling Corticocancellous TypePossesses space maintenance characteristics and dense structural integrity Structure Cortical TypeDense structure allows for predictable maintenance of space Cancellous TypeScaffold-like structure provides ideal environment for vascularization and subsequent regeneration Corticocancellous TypeCombines the structure of cancellous and cortical in one package  

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Description SigmaOss™ is an allograft that can be used alone or in combination with other grafting materials. It is available in a range of types, and each type behaves and generates results differently depending on the clinical needs which are primarily volume preservation and/or rapid regeneration. SigmaOss™ is ideal for cases such as ridge augmentation, periodontal defect, sinus grafting, extraction site preservation, and more. Cortical Type Mineralized or Demineralized SMALL LARGE Volume MCOSG025 MCOLG025 0.25 cc MCOSG050 MCOLG050 0.5 cc MCOSG100 MCOLG100 1.0 cc MCOSG200 MCOLG200 2.0 cc SMALL Volume DCOSG025 0.25 cc DCOSG050 0.5 cc DCOSG100 1.0 cc DCOSG200 2.0 cc Cancellous Type Mineralized SMALL LARGE Volume MCASG025 MCALG025 0.25 cc MCASG050 MCALG050 0.5 cc MCASG100 MCALG100 1.0 cc MCASG200 MCALG200 2.0 cc Corticocancellous Type Mineralized or Demineralized SMALL LARGE Volume MCCSG025 MCCLG025 0.25 cc MCCSG050 MCCLG050 0.5 cc MCCSG100 MCCLG100 1.0 cc MCCSG200 MCCLG200 2.0 cc SMALL Volume DCCSG025 0.25 cc DCCSG050 0.5 cc DCCSG100 1.0 cc DCCSG200 2.0 cc Indications for Use Application Ridge augmentation, periodontal defect, sinus grafting, extraction site preservation Safety Made possible through the generosity of American donors whose eligibility (screening and testing) is performed in accordance with AATB standards and FDA regulations Versatility Capable of grafted alone or in combination with other grafting materials Capabilities Cortical Type Slow-resorbing characteristic allows for extended period of space maintenance Cancellous Type Ideal for defects that require rapid remodeling Corticocancellous Type Possesses space maintenance characteristics and dense structural integrity Structure Cortical Type Dense structure allows for predictable maintenance of space Cancellous Type Scaffold-like structure provides ideal environment for vascularization and subsequent regeneration Corticocancellous Type Combines the structure of cancellous and cortical in one package

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Description SigmaOss™ is an allograft that can be used alone or in combination with other grafting materials. It is available in a range of types, and each type behaves and generates results differently depending on the clinical needs which are primarily volume preservation and/or rapid regeneration. SigmaOss™ is ideal for cases such as ridge augmentation, periodontal defect, sinus grafting, extraction site preservation, and more. Cortical Type Mineralized or Demineralized SMALL LARGE Volume MCOSG025 MCOLG025 0.25 cc MCOSG050 MCOLG050 0.5 cc MCOSG100 MCOLG100 1.0 cc MCOSG200 MCOLG200 2.0 cc SMALL Volume DCOSG025 0.25 cc DCOSG050 0.5 cc DCOSG100 1.0 cc DCOSG200 2.0 cc Cancellous Type Mineralized SMALL LARGE Volume MCASG025 MCALG025 0.25 cc MCASG050 MCALG050 0.5 cc MCASG100 MCALG100 1.0 cc MCASG200 MCALG200 2.0 cc Corticocancellous Type Mineralized or Demineralized SMALL LARGE Volume MCCSG025 MCCLG025 0.25 cc MCCSG050 MCCLG050 0.5 cc MCCSG100 MCCLG100 1.0 cc MCCSG200 MCCLG200 2.0 cc SMALL Volume DCCSG025 0.25 cc DCCSG050 0.5 cc DCCSG100 1.0 cc DCCSG200 2.0 cc Indications for Use Application Ridge augmentation, periodontal defect, sinus grafting, extraction site preservation Safety Made possible through the generosity of American donors whose eligibility (screening and testing) is performed in accordance with AATB standards and FDA regulations Versatility Capable of grafted alone or in combination with other grafting materials Capabilities Cortical Type Slow-resorbing characteristic allows for extended period of space maintenance Cancellous Type Ideal for defects that require rapid remodeling Corticocancellous Type Possesses space maintenance characteristics and dense structural integrity Structure Cortical Type Dense structure allows for predictable maintenance of space Cancellous Type Scaffold-like structure provides ideal environment for vascularization and subsequent regeneration Corticocancellous Type Combines the structure of cancellous and cortical in one package

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A combination of 90% bovine granules (hydroxyapatite) and 10% collagen fibers molded into a block form Bovine granule composition, InterOss®, exhibits a structure similar to human bone which provides an osteoconductive environment for bone ingrowth Porosity of the bovine granules facilitates the exchange of growth factors and allows cells to guide bone formation Highly purified collagen facilitates the adaptation of the bovine granules to the defect site Exceptional handling and ease of use

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A combination of 90% bovine granules (hydroxyapatite) and 10% collagen fibers molded into a block form Bovine granule composition, InterOss®, exhibits a structure similar to human bone which provides an osteoconductive environment for bone ingrowth Porosity of the bovine granules facilitates the exchange of growth factors and allows cells to guide bone formation Highly purified collagen facilitates the adaptation of the bovine granules to the defect site Exceptional handling and ease of use

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A combination of 90% bovine granules (hydroxyapatite) and 10% collagen fibers molded into a block form Bovine granule composition, InterOss®, exhibits a structure similar to human bone which provides an osteoconductive environment for bone ingrowth Porosity of the bovine granules facilitates the exchange of growth factors and allows cells to guide bone formation Highly purified collagen facilitates the adaptation of the bovine granules to the defect site Exceptional handling and ease of use

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A combination of 90% bovine granules (hydroxyapatite) and 10% collagen fibers molded into a block form Bovine granule composition, InterOss®, exhibits a structure similar to human bone which provides an osteoconductive environment for bone ingrowth Porosity of the bovine granules facilitates the exchange of growth factors and allows cells to guide bone formation Highly purified collagen facilitates the adaptation of the bovine granules to the defect site Exceptional handling and ease of use

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A combination of 90% bovine granules (hydroxyapatite) and 10% collagen fibers molded into a plug form Bovine granule composition, InterOss®, exhibits a structure similar to human bone which provides an osteoconductive environment for bone ingrowth Porosity of the bovine granules facilitates the exchange of growth factors and allows cells to guide bone formation Highly purified collagen facilitates the adaptation of the bovine granules to the defect site Exceptional handling and ease of use

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A combination of 90% bovine granules (hydroxyapatite) and 10% collagen fibers molded into a block form Bovine granule composition, InterOss®, exhibits a structure similar to human bone which provides an osteoconductive environment for bone ingrowth Porosity of the bovine granules facilitates the exchange of growth factors and allows cells to guide bone formation Highly purified collagen facilitates the adaptation of the bovine granules to the defect site Exceptional handling and ease of use

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Description SigmaOss™ Fiber is 100% cortical bone fibers demineralized to expose their natural growth factors, enabling its osteoinductive potential by providing a scaffold structure that promotes cellular attachment. SigmaOss™ Fiber’s versatility allows for the graft to mold into the desired shape upon hydration. As a result of this moldability and versatility, the graft is confined to the desired shape and site, preventing the migration to adjacent tissue. Cortical Type Demineralized REF Volume DCOF100 1.0 cc DCOF250 2.5 cc DCOF500 5.0 cc Indications for Use Application Ridge augmentation, periodontal defect, sinus grafting, extraction site preservation Safety Made possible through the generosity of American donors whose eligibility (screening and testing) is performed in accordance with AATB standards and FDA regulations Capabilities Woven fiber network allows for easy shaping of graft to desired form Versatility Osteoinductive grafting material capable of grafted alone or in combination with other grafting materials Downloads SigmaOss™ Fiber Flyer

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Description SigmaOss™ is an allograft that can be used alone or in combination with other grafting materials. It is available in a range of types, and each type behaves and generates results differently depending on the clinical needs which are primarily volume preservation and/or rapid regeneration. SigmaOss™ is ideal for cases such as ridge augmentation, periodontal defect, sinus grafting, extraction site preservation, and more. Cortical Type Mineralized or Demineralized SMALL LARGE Volume MCOSG025 MCOLG025 0.25 cc MCOSG050 MCOLG050 0.5 cc MCOSG100 MCOLG100 1.0 cc MCOSG200 MCOLG200 2.0 cc SMALL Volume DCOSG025 0.25 cc DCOSG050 0.5 cc DCOSG100 1.0 cc DCOSG200 2.0 cc Cancellous Type Mineralized SMALL LARGE Volume MCASG025 MCALG025 0.25 cc MCASG050 MCALG050 0.5 cc MCASG100 MCALG100 1.0 cc MCASG200 MCALG200 2.0 cc Corticocancellous Type Mineralized or Demineralized SMALL LARGE Volume MCCSG025 MCCLG025 0.25 cc MCCSG050 MCCLG050 0.5 cc MCCSG100 MCCLG100 1.0 cc MCCSG200 MCCLG200 2.0 cc SMALL Volume DCCSG025 0.25 cc DCCSG050 0.5 cc DCCSG100 1.0 cc DCCSG200 2.0 cc Indications for Use Application Ridge augmentation, periodontal defect, sinus grafting, extraction site preservation Safety Made possible through the generosity of American donors whose eligibility (screening and testing) is performed in accordance with AATB standards and FDA regulations Versatility Capable of grafted alone or in combination with other grafting materials Capabilities Cortical Type Slow-resorbing characteristic allows for extended period of space maintenance Cancellous Type Ideal for defects that require rapid remodeling Corticocancellous Type Possesses space maintenance characteristics and dense structural integrity Structure Cortical Type Dense structure allows for predictable maintenance of space Cancellous Type Scaffold-like structure provides ideal environment for vascularization and subsequent regeneration Corticocancellous Type Combines the structure of cancellous and cortical in one package

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Description InterOss® Collagen Block is anorganic hydroxyapatite-collagen composite for use in periodontal, oral, and maxillofacial surgery. It is a combination of 90% bovine granules and 10% collagen fibers molded into a block form (also available as a plug). InterOss® granules exhibit a natural mineralized bone structure, similar to human bone, and provides an osteoconductive environment for the ingrowth of the adjacent viable bone. Its excellent porosity allows the grafting material to act as a conduit for the exchange of body fluids and growth factors while allowing cells to guide bone formation. Highly purified collagen facilitates the adaptation of these granules to the defect site, bringing about exceptional handling and ease of use. Reference Numbers REF Size Weight IOC-50 6 x 6 x 3 mm 50 mg IOC-100 6 x 6 x 6 mm 100 mg IOC-250 7 x 8 x 9 mm 250 mg IOC-350 8 x 9 x 10 mm 350 mg IOC-500 9 x 10 x 12 mm 500 mg Indications for Use InterOss® Collagen is indicated for the filling of extraction sockets to enhance the preservation of the alveolar ridge. The product is recommended for: Filling of extraction sockets to enhance preservation of the alveolar ridge Filling of periodontal defects in extraction sockets in conjunction with products intended for guided tissue regeneration (GTR) and guided bone regeneration (GBR) Studies InterOss® Collagen has 10% of collagen since collagen plays an important element of extracellular matrix which regulates cell functions. It is pliable and moldable, making it easy to handle. InterOss® Collagen is validated and documented in case of studies through clinicians involving procedures such as horizontal/vertical augmentation. Downloads InterOss® Collagen Block Flyer InterOss® Collagen Booklet

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Description InterOss® Syringe is a natural hydroxyapatite bone grafting material for use in dentistry. Made from a proven multi-step purification process which leaves only a bone composition, it is a highly purified osteoconductive material for bone regeneration. Having an interconnected network of macro and micro pores and large inner surface areas that provides an ideal environment for cell attachment, InterOss® is chemically and structurally comparable to mineralized human bone. InterOss® Syringe is designed to deliver InterOss® granules more precisely to the intended treatment site without having to use sterile instruments. It is available in sterilized granule form and is dedicated for single uses (also available in a vial). Small Granules (0.25 – 1.0 mm) REF Volume IOSGS025 0.25 cc IOSGS050 0.5 cc IOSGS100 1.0 cc Large Granules (1.0 – 2.0 mm) REF Volume IOLGS050 0.5 cc IOLGS100 1.0 cc Indications for Use InterOss® is recommended for: Filling of peri-implant defects in conjunction with products intended for guided bone regeneration (GBR) Filling of periodontal defects in conjunction with products intended for guided tissue regeneration (GTR) and guided bone regeneration (GBR) Reconstruction or augmentation of the alveolar ridge Filling of periodontal defects Filling of defects after root resection, apicectomy, and cystectomy Filling of extraction sockets to enhance preservation of the alveolar ridge Elevation of the maxillary sinus floor Studies InterOss® is 100% natural, biocompatible, highly purified, and has a large inner surface area, multi-porosity, and long term stability. It is validated and documented in clinical studies through universities in the US and abroad and case studies through clinicians involving procedures such as horizontal/vertical augmentation, sinus augmentation, and sinus elevation. Downloads InterOss® Syringe Flyer InterOss® Booklet

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Description InterOss® is a natural hydroxyapatite bone grafting material for use in dentistry. Made from a proven multi-step purification process which leaves only a bone composition, it is a highly purified osteoconductive material for bone regeneration. Having an interconnected network of macro and micro pores and large inner surface areas that provides an ideal environment for cell attachment, InterOss® is chemically and structurally comparable to mineralized human bone. It is available in sterilized granule form and is dedicated for single uses (also available in a syringe). Small Granules (0.25 – 1.0 mm) REF Volume Weight IOSG025 0.54 cc 0.25 g IOSG050 1.08 cc 0.5 g IOSG100 2.16 cc 1.0 g IOSG200 4.32 cc 2.0 g Large Granules (1.0 – 2.0 mm) REF Volume Weight IOLG050 2.0 cc 0.5 g IOLG100 4.0 cc 1.0 g IOLG200 8.0 cc 2.0 g Indications for Use InterOss® is recommended for: Filling of peri-implant defects in conjunction with products intended for guided bone regeneration (GBR) Filling of periodontal defects in conjunction with products intended for guided tissue regeneration (GTR) and guided bone regeneration (GBR) Reconstruction or augmentation of the alveolar ridge Filling of periodontal defects Filling of defects after root resection, apicectomy, and cystectomy Filling of extraction sockets to enhance preservation of the alveolar ridge Elevation of the maxillary sinus floor Studies InterOss® is 100% natural, biocompatible, highly purified, and has a large inner surface area, multi-porosity, and long term stability. It is validated and documented in clinical studies through universities in the US and abroad and case studies through clinicians involving procedures such as horizontal/vertical augmentation, sinus augmentation, and sinus elevation. Downloads InterOss® Flyer InterOss® Booklet

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